Flexible automated DNA and RNA workflows

Key features

• High yields, integrity and purity of nucleic acids with proven performance in long-read sequencing, NGS, PCR, MLPA etc.
• sample volumes up to 10 ml, 1- 192 samples per run, diverse tubes/sample types in a single run, downstream normalization/assay setup/eluate transfer, customized pipetting for viscous samples
• On-deck 1D/2D barcode scanning, LIMS compatible log files, customizable run reports
• 100% traceability, tracked reagent/tip consumption, safe travel paths, UV disinfection, drop cover
• Optimized reagent dispensing (no expensive cartridges), multi-kit use with switchbox, on-deck heating/cooling/shaking options
• Status lights, fast start-up, intuitive software, guided setup and maintenance, user-friendly programming, email notification of errors

The chemagic Prime instrument is a powerful solution for high-throughput automated DNA and RNA purification and automated assay setup. The chemagic Prime instrument combines chemagen’s patented M-PVA Magnetic Bead Technology with liquid handling capabilities, providing automated sample preparation by handling various primary sample tubes and fully automated isolation of ultra-pure, high integrity nucleic acids from diverse sample types. The instrument performs downstream processing e.g. PCR setup, normalization or eluate transfer to storage tubes.

The platform boasts fully traceable sample preparation, consistent performance and the flexibility to meet custom workflows demands. Benefit from its diverse tube handling, automated barcode tracking, quality assurance features to reduce cross-contamination, high throughput capability (up to 192 samples/run), large sample volume range (up to 10 ml), and user-friendly operation. With a wide selection of kits, the instrument can isolate DNA, RNA, cfDNA, pathogen nucleic acids and more, enabling the usage of one system for multiple assays. The technology behind it utilizes transiently magnetized rods to attract beads after binding to nucleic acids, obtaining nucleic acids of high yield, integrity and purity, proven to increase downstream success in diverse applications including long read sequencing, NGS, MLPA, PCR and more.

Applications with chemagic Prime instrument

chemagic Prime Kits

Kits are available for the isolation of DNA and RNA from various specimens such as whole blood, saliva, plasma, and many more. We provide chemagic Prime Kits that have been validated on the chemagic Prime instrument.

All kits come ready-to-use with plastic consumables included and are based on well-established chemagic M-PVA Magnetic Bead and buffer chemistry. For applications not listed, please contact us. 

References

1. Costa E, Rocha D, Lopes JIF, et al. Detection of Plasmodium spp. in asymptomatic blood donors by the new Brazilian NAT PLUS HIV/HBV/HCV/Malaria Bio-Manguinhos kit. Transfusion. 2024;64(3):501-509. doi:10.1111/trf.17726
2. Bui DT, Ton ANV, Nguyen CTD, et al. Pathogenic/likely pathogenic mutations identified in Vietnamese children diagnosed with autism spectrum disorder using high-resolution SNP genotyping platform. Sci Rep. 2024;14(1):2360. Published 2024 Jan 29. doi:10.1038/s41598-024-52777-y
3. Döhla M, Schulte B, Wilbring G, et al. SARS-CoV-2 in Environmental Samples of Quarantined Households. Viruses. 2022;14(5):1075. Published 2022 May 17. doi:10.3390/v14051075
4. Lou EG, Sapoval N, McCall C, et al. Direct comparison of RT-ddPCR and targeted amplicon sequencing for SARS-CoV-2 mutation monitoring in wastewater. Sci Total Environ. 2022;833:155059. doi:10.1016/j.scitotenv.2022.155059
5. Streeck H, Schulte B, Kümmerer BM, et al. Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany. Nat Commun. 2020;11(1):5829. Published 2020 Nov 17. doi:10.1038/s41467-020-19509-y
6. LaTurner ZW, Zong DM, Kalvapalle P, et al. Evaluating recovery, cost, and throughput of different concentration methods for SARS-CoV-2 wastewater-based epidemiology. Water Res. 2021;197:117043. doi:10.1016/j.watres.2021.117043

The chemagic™ 360 instrument: a compact solution for automated DNA and RNA purification

The genomic analysis of large numbers of samples requires a reliable system for the automated isolation of DNA and RNA. With dimensions of only 80 x 80 cm and its unique sample volume flexibility, the chemagic™ 360 instrument is an innovative system that can be adapted to fit almost all of your automated DNA and RNA purification needs. By using chemagen's well-established M-PVA Magnetic Bead technology, the chemagic™ 360 instrument provides high yields of ultra-pure nucleic acids suitable for a wide range of downstream applications such as NGS, MLPA, genotyping, and PCR.

The exclusive chemagic™ technology for nucleic acid purification

Unlike other automated nucleic acid purification instruments, the chemagic™ 360 system uses transiently magnetized rods to attract the beads after binding to the nucleic acids. This key technological feature and the concerted rotation of the rods allow optimal sample mixing during the homogenization and washing steps, increasing the yield and purity of the extracted nucleic acid molecules. The transfer of the magnetic beads between tubes minimizes the possibility of sample contamination between purification steps.

Instrument specifications

Equipped with barcode-reader and QA software, the chemagic 360 instrument complies with LIMS compatibility and modern quality assurance standards. The modular set up of the system and convenient loading procedure allow its integration with standard liquid handling robots, such as the Janus® or Sciclone®. Kits are available for the isolation of DNA and RNA from various specimens including liquid (whole blood, saliva, plasma, etc.) and solid samples (tissues, FFPE samples, etc.). For research use only. We also offer an IVD-certified* version of the chemagic™ 360 instrument.

For more information, please download the brochure below or contact us.

References

1. Zehir, A., Benayed, R., Shah, R. et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med 23, 703–713 (2017).