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chemagic™ Prime Junior instrument

The chemagic™ Prime Junior instrument for automated RNA and DNA isolation

The chemagic™ Prime™ Junior instrument: Streamlined workflow from primary sample to DNA and RNA isolation to assay setup

Designed with flexibility in mind – The chemagic Prime Junior instrument enables a streamlined workflow from primary sample to ready to use nucleic acids. Eluate handling such as transfer to storage tubes is included, moreover some deckspace is reserved to fulfill further automation needs in PCR/NGS/Assay setup. It is dedicated for automated RNA and DNA isolation from all related sample materials like blood, plasma, saliva, urine, swabs, feces. Reveal what‘s possible in next generation of automation. Flexibly run between 1 to 48 samples (24 per batch) of 200 - 1000 µl body fluids without any waste of reagents.

Fully automated RAN and DNA extraction

Workflow features

  • Barcode reading ensures full sample traceability
  • Automated sample handling eliminates user related variabilities
  • M-PVA Magnetic Bead based nucleic acid extraction with preinstalled protocols
  • Optimized kits bearing quality, recovery rate and speed in mind
  • User-friendly interface and status lights for easy operation
  • Deckspace reserved to fulfill automation needs in PCR/NGS/Assay setup
Fully automated RAN and DNA extraction

Supported applications

  • Genomic DNA and RNA isolation from blood, cells, saliva and tissue for biobanking
  • Isolation of viral/bacterial nucleic acids from serum/plasma pools
  • Processing body fluids for research applications
  • Extraction of high molecular weight DNA for long range sequencing
  • Isolation of DNA from various samples for microbiome analysis

The use of the chemagic™ technology ensures efficient isolation of high-quality nucleic acids.

Kits

Bearing quality, recovery rates and speed in mind the chemagic Prime Junior runs with dedicated nucleic acid extraction kits that were developed to support either genome research or applications that require viral or bacterial nucleic acids as starting point. Preinstalled protocols allow convenient operation. Due to reserved deckspace and pipetting capabilities PCR setup and sequencing kit adaptions are available on request.

Catalog. No.Kit NameSample TypeSample VolumePreps/Kit
CMG-1534Junior gDNA Kitblood, buffy coat, saliva, cells, buccal swabs, tissue, FFPE tissue, feces, amniotic fluid200 μl - 800 μl
depending on the sample material		480
CMG-1521Junior Pathogen NA Kitblood, serum, plasma, saliva, sputum, swabs, CVS, urine, feces200 μl - 1000 μl
depending on the sample material		480

For research use only. Not for use in diagnostic procedures.

chemagic Prepito®: Bench top workflow

Bench top instrument for automated RNA and DNA isolation

The chemagic Prepito®: Bench top instrument for automated RNA and DNA isolation

Based on chemagen’s proprietary M-PVA Magnetic Beads technology for high-yield extraction of ultra-pure nucleic acids, the chemagic Prepito® instrument represents the optimal system for laboratories that process less than one hundred samples per day or need to add flexibility to their current high-throughput workflow. This bench top solution for automated nucleic acid isolation is suitable for diverse sample materials.

Bench top instrument for DNA and RNA isolation

Bench top solution for automated nucleic acid extraction

Features at a glance

  • Up to 12 samples per run
  • Sample volume capacity up to 1 ml
  • Kits available for a large variety of sample materials (e.g., blood, serum and plasma, tissues, etc.)
  • Cost-efficient integrated buffer dispensing and use of standard plastic devices
  • Barcode reader for optimal sample management
  • Touch panel software for ease of use
  • USB slot for simple data transfer

The chemagic Prepito® exploits transiently magnetized rods to ensure thorough mixing of the primary samples (when the magnetic field is turned off) and efficient collection of the magnetic beads (when the magnetic field is turned on).

Magnetic Beads for nucleic acid purification

Designed for the use with the thoroughly validated Prepito® Kits for nucleic acid extraction, the chemagic Prepito® instrument keeps running costs lower by automatically dispensing the required amount of reagents directly from bottles rather than pre-filled cartridges. For research use only. Revvity also offers an IVD-certified version of the chemagic Prepito®.

Product overview

Product no.Kit nameSample materialSample volumeTarget
CMG-2002Prepito DNA Blood250 KitBlood, buffy coat, saliva250 µlgDNA
CMG-2003Prepito DNA Blood400 KitBlood, buffy coat, saliva400 µlgDNA
CMG-2004Prepito DNA Blood600 KitBlood, buffy coat, saliva600 µlgDNA
CMG-2010Prepito DNA Tissue10 KitTissue, cells10 mg tissuegDNA
CMG-2017Prepito Viral DNA/RNA300 KitBody fluidsUp to 200 µlPathogen NA
CMG-2018Prepito Viral DNA/RNA1k KitBody fluidsUp to 300 µlPathogen NA
CMG-2021Prepito NA Body Fluid KitBlood, body fluidsUp to 1 mlPathogen NA
CMG-2027Prepito FFPE KitFFPE10 µm sectionsgDNA
CMG-2034Prepito Cyto Pure KitDiverse sample materials250 µl fluid, 10 mg tissue, 3-5 ml amniotic fluidgDNA
CMG-2039Prepito RNA KitDiverse sample materials250 µl fluid, 10 mg tissueRNA

For research use only. Not for use in diagnostic procedures.

Fully automated DNA and RNA purification: chemagic Prime

The chemagic Prime instrument for fully automated nucleic acid purification

Flexible automated DNA and RNA workflows

The chemagic Prime instrument for fully automated nucleic acid purification

chemagic™ Prime™ instrument

  • Performance
  • Flexibility
  • Automated traceability
  • Quality assurance
  • Efficiency
  • Ease of operation

The chemagic Prime instrument - Testimonial

"We perform HLA typing of unrelated donors for various donor registries using high throughput NGS. We have been using the chemagen kits in conjunction with the MSM I system to isolate the DNA from these samples for many years now. As our sample numbers increased drastically over the past two years, we were in the need for additional systems for high throughput DNA isolation. Therefore, we recently bought two chemgic Prime systems, which we use to process an average of 4000-5000 samples per month. Revvity offers an excellent service with very competent programmers. All of our wishes regarding specified protocols were fulfilled to our utmost satisfaction. We also appreciate the high quality of the isolated DNA that we obtain from both, blood samples and buccal swabs."

DRK Blutspende, Germany

 

Sprungziel Features

Features

Key features

  • High yields, integrity and purity of nucleic acids with proven performance in long-read sequencing, NGS, PCR, MLPA etc.
  • sample volumes up to 10 ml, 1- 192 samples per run, diverse tubes/sample types in a single run, downstream normalization/assay setup/eluate transfer, customized pipetting for viscous samples
  • On-deck 1D/2D barcode scanning, LIMS compatible log files, customizable run reports
  • 100% traceability, tracked reagent/tip consumption, safe travel paths, UV disinfection, drop cover
  • Optimized reagent dispensing (no expensive cartridges), multi-kit use with switchbox, on-deck heating/cooling/shaking options
  • Status lights, fast start-up, intuitive software, guided setup and maintenance, user-friendly programming, email notification of errors

Features

The chemagic Prime instrument is a powerful solution for high-throughput automated DNA and RNA purification and automated assay setup. The chemagic Prime instrument combines chemagen’s patented M-PVA Magnetic Bead Technology with liquid handling capabilities, providing automated sample preparation by handling various primary sample tubes and fully automated isolation of ultra-pure, high integrity nucleic acids from diverse sample types. The instrument performs downstream processing e.g. PCR setup, normalization or eluate transfer to storage tubes.

The platform boasts fully traceable sample preparation, consistent performance and the flexibility to meet custom workflows demands. Benefit from its diverse tube handling, automated barcode tracking, quality assurance features to reduce cross-contamination, high throughput capability (up to 192 samples/run), large sample volume range (up to 10 ml), and user-friendly operation. With a wide selection of kits, the instrument can isolate DNA, RNA, cfDNA, pathogen nucleic acids and more, enabling the usage of one system for multiple assays. The technology behind it utilizes transiently magnetized rods to attract beads after binding to nucleic acids, obtaining nucleic acids of high yield, integrity and purity, proven to increase downstream success in diverse applications including long read sequencing, NGS, MLPA, PCR and more.

Applications

Features

Applications with chemagic Prime instrument

High-throughput blood donor screening

High-throughput blood donor screening

Using the chemagic Prime instrument, up to 552 blood bags are analyzed routinely, with high traceability and sensitivity for detecting HIV (AIDS virus), HCV (hepatitis C virus), HBV (hepatitis B virus) and malaria with the NAT Plus HIV/HBV/HCV/Malaria Kit developed by the Oswaldo Cruz Foundation (Bio-Manguinhos/Fiocruz). This has helped reduce the waiting period to donate blood after visiting an endemic area from 1 year to 1 month and has successfully reduced the risk of pathogen transmission due to contaminated blood1.

Genetic study of Autism Spectrum Disorder in Vietnamese children

The chemagic Prime instrument played a crucial role in isolating high-quality DNA from 254 saliva samples, which was essential for the study’s subsequent high resolution SNP genotyping. This technique enabled the identification of pathogenic and likely pathogenic mutations in children with autism spectrum disorder. The automation and precision of the chemagic Prime system significantly enhanced the efficiency and consistency of sample processing, underscoring its importance in large-scale genetic research2.

chemagic Prime for wastewater surveillance

Pathogen surveillance from swabs and wastewater

Multiple studies have demonstrated the application of the chemagic Prime instrument for the high-throughput and sensitive detection of SARS-CoV-2 from samples including blood, pharyngeal swabs, environmental surface swabs and wastewater3,4,5,6. The ability of chemagic Kits to extract nucleic acids from a wide range of pathogens and the unique feature of the chemagic Prime instrument in handling diverse sample/eluate tubes and plates makes it a reliable yet versatile solution.

Kits

chemagic Prime Kits

Kits are available for the isolation of DNA and RNA from various specimens such as whole blood, saliva, plasma, and many more. We provide chemagic Prime Kits that have been validated on the chemagic Prime instrument.

All kits come ready-to-use with plastic consumables included and are based on well-established chemagic M-PVA Magnetic Bead and buffer chemistry. For applications not listed, please contact us. 

Brochure

References

For research use only. Not for use in diagnostic procedures.

chemagic™ 360 instrument: Automated DNA and RNA purification

The chemagic 360 instrument for automated DNA and RNA extraction

The chemagic™ 360 instrument: a compact solution for automated DNA and RNA purification

The genomic analysis of large numbers of samples requires a reliable system for the automated isolation of DNA and RNA. With dimensions of only 80 x 80 cm and its unique sample volume flexibility, the chemagic™ 360 instrument is an innovative system that can be adapted to fit almost all of your automated DNA and RNA purification needs. By using chemagen's well-established M-PVA Magnetic Bead technology, the chemagic™ 360 instrument provides high yields of ultra-pure nucleic acids suitable for a wide range of downstream applications such as NGS, MLPA, genotyping, and PCR.

Features at a glance

  • Optimized design to prevent cross-contamination
  • Input sample volumes from 50 µl - 18 ml
  • Throughput from 12, 24, 96 samples/run
  • Ultra-fast protocols available for DNA purification
  • Flexible reagent dispensing to keep running expenses low
  • User-friendly interface allows simple and fast installation
  • Easy to integrate with liquid handling platforms

Technology

The exclusive chemagic™ technology for nucleic acid purification

Unlike other automated nucleic acid purification instruments, the chemagic™ 360 system uses transiently magnetized rods to attract the beads after binding to the nucleic acids. This key technological feature and the concerted rotation of the rods allow optimal sample mixing during the homogenization and washing steps, increasing the yield and purity of the extracted nucleic acid molecules. The transfer of the magnetic beads between tubes minimizes the possibility of sample contamination between purification steps.

What customers say...

Tessara Baldi, Senior Automation Engineer​, Memorial Sloan Kettering Cancer Centre, New York

Memorial Sloan Kettering Cancer Center (MSK) is a leading institution in cancer care, research, and personalized treatment, utilizing innovative technologies like chemagic for DNA extraction from tumor and FFPE tissues, bone marrow and blood to improve patient outcomes1. Hear what they have to say!

What customers say...

Chris Piccirillo, Sampled, Piscataway, USA

Sampled is one of the world’s largest biorepositories with nearly 25 years of experience. Their core competence is storing, managing, analyzing and, transporting biological samples for medical research, or other scientific endeavors. Their expertise in handling samples makes them a valuable resource for researchers and organizations.

Instrument Specifications

Instrument specifications

Equipped with barcode-reader and QA software, the chemagic 360 instrument complies with LIMS compatibility and modern quality assurance standards. The modular set up of the system and convenient loading procedure allow its integration with standard liquid handling robots, such as the Janus® or Sciclone®. Kits are available for the isolation of DNA and RNA from various specimens including liquid (whole blood, saliva, plasma, etc.) and solid samples (tissues, FFPE samples, etc.). For research use only. We also offer an IVD-certified* version of the chemagic™ 360 instrument.

Automated DNA and RNA purification

Instrument specifications

  • Throughput:
    • Single run sample capacity: 12, 24, 96-well depending on the configuration
    • Sample volume: from 10 μl to 10 ml
    • Single run duration: depends on the sample type, about 45 minutes for blood samples
  • Dimensions and weight:
    • Width: 80 cm
    • Depth: 80 cm
    • Height: 90 cm
    • Weight: 140 kg

For more info

For more information, please download the brochure below or contact us.

For research use only. Not for use in diagnostic procedures.

* Products may not be licensed in accordance with the laws in all countries, such as the United States and Canada. Please check with your local representative for availability.